T 0205/95 (Sulfonamide dioxides/MERCK) 16-09-1997
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4-alkylamino-6-(C3-5-hydrocarbyl)thieno [2,3-b] thiopyran-2- sulfonamide-7, 7-dioxides
Summary of Facts and Submissions
I. The appeal lies from the Examining Division's decision, dispatched on 21 October 1994, refusing European patent application No. 91 304 401.2, published as EP-A-0 457 586, due to lack of novelty.
The Examining Division was of the opinion that the subject-matter described in document (A), EP-A-0 453 288, overlapped with the one claimed in the set of claims filed with letter of 25 July 1994, with Claim 1 reading:
"1. A compound of structural formula:
FORMULA
or diastereomers or enantiomers or mixtures thereof or an ophthalmologically acceptable salt thereof wherein:
R is ethyl, n-propyl or isopropyl; and
R1 is (a) C3-5 alkyl,
(b) C3-5 alkenyl, or
(c) C3-5 alkynyl,
with the exception of the compound trans-5,6-dihydro-4-isopropylamino-6-propyl-4H-thieno[2,3-b] thiopyran-2-sulphonamide-7,7-dioxide." (emphasis added)
More particularly, in the Examining Division's view, the disclaimer (see emphasised text) was not suitable to make the claimed subject-matter novel, since the teaching of document (A) enabled a skilled person to prepare at least those claimed compounds in which R and R1 are C1-4 alkyl (reference was made to T 12/90 of 23. August 1990).
II. The Appellant filed with telefax of 21 August 1997 a set of 9 claims, reading:
"1. A compound of structural formula:
FORMULA
or diastereomers or enantiomers or mixtures thereof or an ophthalmologically acceptable salt thereof wherein:
R is ethyl, n-propyl or isopropyl; and
R1 is (a) C5 alkyl,
(b) C3-5 alkenyl,
(c) C3-5 alkynyl, or
(d) n-propyl, where R is ethyl or n-propyl."
"2. The compound of Claim 1 wherein R is ethyl and R1 is n-propyl."
"3. The compound of Claim 1 wherein R is n-propyl and R1 is n-propyl."
"4. The compound of Claim 1 wherein R is ethyl and R1 is allyl."
"5. The compound of Claim 2 or Claim 4 which is the trans (S,S) enantiomer or cis (S,R) enantiomer.
"6. The compound of Claim 3 which is the trans (+) diastereomer."
"7. The compound of Claim 3 which is the trans (-) enantiomer."
"8. An ophthalmological formulation for the treatment of ocular hypertension and glaucoma comprising an ophthalmologically acceptable carrier and a compound of any one of Claims 1 to 7."
"9. The use of a compound of any one of Claims 1 to 7 for the manufacture of a medicament for treating ocular hypertension or glaucoma."
The Appellant submitted that these claims were novel over document (A), since the compounds according to Claim 1 having as R1 a group (a), (b) or (c) do not overlap in a generic sense with the disclosure of document (A) and neither of the two compounds covered by group (d) is, according to the principle described in T 7/86 (OJ EPO 1988, 381), specifically disclosed in document (A).
III. With telefax of 21 August 1997 the Appellant requested that the appealed decision be set aside and that a patent be granted on the basis of the revised Claims 1 to 9 submitted with that telefax.
Reasons for the Decision
1. The appeal is admissible.
2. Amendments
Claim 1 essentially differs from Claim 1 as originally filed by the fact that R1 may be
(a) n-propyl, where R is ethyl or n-propyl, which compounds were both disclosed in the originally filed application (see example 1 and the first and second compound in any of Tables I, II and III), or
(b) C5 alkyl, which compounds were disclosed in Claim 1 of the application as originally filed by C3-5 alkyl.
Claims 2 and 4 correspond with original Claims 2 respectively 3 and, the compound defined in Claim 3 was disclosed as the first and second compound in Table I and the second compound in Table II, whereas the enantiomers defined in Claim 5 were described on page 5, lines 7 to 13 (page 3, lines 26 to 29, of the published version), the diastereomer and the enantiomer defined in Claim 6 respectively 7 correspond with the first respectively second compound of Table I of the originally filed application and the Claims 8 and 9 are duly supported by original Claims 9 and 10.
3. Novelty
The application in suit was mainly refused because the disclaimer in the then pending Claim 1 (see the emphasized part of the Claim presented in point I above) was considered not to be suitable to remove the novelty destroying overlap between the claimed subject-matter and the disclosure of document (A), which belongs to the state of the art according to Article 54(3) EPC.
Since the objected disclaimer no longer figures in present Claim 1 and since by restricting the alkyl group in the definition of R1 to C5 alkyl and, where R is ethyl or n-propyl, to n-propyl the overlap with the disclosure of document (A) has been removed, the main reason for refusing the patent application no longer exists.
Since document (A) does not describe compounds as defined in present Claim 1 wherein R1 is C5 alkyl, C3-5 alkenyl or C3-5 alkynyl and since the two individual compounds according to present Claim 1, wherein R is ethyl or n-propyl and R1 is n-propyl are not specifically mentioned therein, Claim 1 is novel over document (A). This conclusion is in conformity with the jurisprudence of the Boards of Appeal of the EPO, ruling that a document disclosing polysubstituted chemical substances does not disclose each individual compound if the individual compounds can only be derived from the generic disclosure by selecting one substituent from each of two or more lists of substituents (see T 7/86 OJ EPO 1988, 381, point 5.1 of the reasons and T 12/90 of 23 August 1990, point 3.3 of the reasons).
Moreover, since none of the individual compounds defined in Claims 2 to 7 were disclosed in document (A) and Claims 8 and 9 derive their novelty from the novelty of the compounds defined in Claims 1 to 7, the Board concludes that also these claims are novel over document (A).
4. Since the appealed decision only concerned the novelty of the claimed subject-matter over the teaching of document (A), the Board considers that it would not be appropriate at the present stage of the proceedings to deal with the novelty over other documents and with the further requirements of the EPC, such as the issue of inventive step, as for the Board to do so would deprive the Applicant of the possibility of having these issues decided by two instances. Therefore, the Board has decided to invoke its power under Article 111(1) EPC and to remit the case to the Examining Division for further prosecution.
ORDER
For these reasons it is decided that:
1. The decision under appeal is set aside.
2. The matter is remitted to the Examining Division for further consideration on the basis of the request submitted with telefax on 21 August 1997.