T 1617/08 (Enzyme containing microgranule/GENENCOR INTERNATIONAL) 20-12-2012

Reasons for the decision

Main request

1. The main request was filed one month before oral proceedings. Except for the deletion of claims 5, 8 and 12, it is identical with auxiliary request 1 which had originally been filed with the grounds of appeal but had later been withdrawn. The appellant reverted to this request in response to comments made by the board in its preliminary communication in respect of the then pending requests. In this communication, the board had addressed issues which had not been raised before in appeal proceedings.

Under these circumstances, the board, exercising its discretion under Article 13(1) RPBA, decided to admit the main request.

Article 123(2)

2. The main request is almost identical with auxiliary request II filed in opposition proceedings on 15 May 2007. The only difference is the particulate form of the carrier of claim 1.

In opposition proceedings, the respondents raised no objections under the provisions of Article 123(2) EPC, and the opposition division held that auxiliary request II before it complied with said requirements.

Thus, the only issue to be assessed is whether the application documents as originally filed directly and unambiguously disclose the microparticles of claim 1 comprising a carrier in particulate form.

3. According to the published international patent application, the invention relates to enzyme microgranules useful in food and feed applications (page 1, first two lines), comprising a suitable carrier (e.g. claim 1). According to "a process aspect" of the claimed invention (cf. page 5, second paragraph), a blend of enzyme and binder is sprayed onto the carrier to build up a granular form. The process feature of spraying an enzyme onto a carrier implies a particulate nature of the carrier material. Furthermore, the exemplary suitable carriers listed in the first paragraph of the section entitled "Detailed Description of the Invention" (cf. page 3) such as e.g. soy flour, soy grits etc. are all in particulate form. Finally, the carriers used in Examples 1 to 10 were all in particulate form.

4. The board is therefore satisfied that the main request meets the requirements of Article 123(2) EPC.

Articles 123(3), 84 and 54 EPC

5. The respondents did not raise any objections under the provisions of Articles 123(3), 84 and 54 EPC and the board sees no need to do so on its own motion.

Article 56 EPC

6. The subject matter of claim 1 is a food grade microgranule comprising a particulate carrier coated with, in that order, a layer comprising a blend of enzyme and a binder or disintegrant, and a polymer coating agent. The microgranules have an average size between 20 to 200 mym.

7. Document D20A represents the closest prior art. It discloses a process for making enzyme containing microgranules in a fluidised bed apparatus which comprises a first fluidised granulation bed and a second fluidised granulation bed, the latter coaxially joined to and located beneath the distributor plate of the first granulation bed. The upper bed is used to coat a water soluble powder material (i.e. a carrier in particulate form) with an enzyme and a binder. The lower bed is used for film-coating. The distributor plate of the upper bed is porous with a single straight hole and the upper end of an air classifier tube is fixed to and opens at the centre of the distributor plate. A gas stream flowing upwards through the classifier tube prevents coated particles in the upper fluidized bed from discharging into the lower bed before they have reached the desired size (mass).

An exemplary carrier material is sodium sulphate (Examples 1 to 3), exemplary binder solutions comprise sodium silicate and one of yellow dextrin, starch or gelatin (e.g. claim 5), and the coating agent is poylethylene glycol (e.g. claim 6). All these compounds are suitable for food or feed applications (cf. document D24), and the exemplary microparticles produced by the method of document D20A have a size range from about 210 to 1000 microns (claim 2 and Examples 1 to 3).

The technique produces no dust pollution and the product can be widely used e.g. in the feed area (cf. abstract and page 1, 1st paragraph, of the description).

Document D20A thus discloses enzyme containing microgranules having all features of claim 1 except for the claimed average size of between 20 and 200 microns (cf. point 6 above).

8. Starting from document D20A, the technical problem underlying the present invention is seen in the provision of alternative enzyme containing microgranules.

9. As a solution to this problem the application proposes the microgranules of claim 1 characterized by an average size between 20 and 200 microns and composed of a particulate carrier coated with an enzyme and a binder, and in turn coated with a water soluble food grade polymer.

10. Example 5 of the patent in suit discloses the production of microgranules consisting of agglomerated soy flour, coated with a blend of hydrolysed starch and cellulase, and in turn coated with algin. According to Table II of Example 5, 76% of the resulting particles have a size between 63 and 250 mym.

11. The board is satisfied that the underlying technical problem is solved.

12. It remains to be established if the claimed solution could be derived in an obvious way either from the disclosure of document D20A alone or upon combination with any other prior art document on file.

13. Document D20A explicitly refers to adjusting the speed of the gas in the classifier tube according to need, "thereby controlling the size of the product granules" (page 4, second paragraph). Exemplary gas velocities for achieving a specific particle size are given in claim 2 and in the examples. Thus, document D20A, although not disclosing particles of the claimed average size, provides the necessary technical means for producing enzyme-containing microgranules with all the features of claim 1.

14. The appellant argued that the skilled person would not have tried to produce particles of the claimed average size between 20 and 200 microns because it would have had strong doubts about the mixing properties of the resulting product.

According to document D16 (page 817, left hand column), components to be mixed should be of the same size if segregation had to be avoided. Therefore, a product with an average size from 20 to 200 microns would not be expected to have good mixing properties.

Furthermore, it was not obvious that particles with the claimed average size could be produced. According to document D10 (page 6, line 10), particles smaller than 100 microns tended to agglomerate, making spherical granulation more difficult.

15. The board is not convinced by these arguments.

No argument has been put forward that it would be technically difficult to produce microgranules of the claimed average size by adjusting the gas flow velocity in the procedure disclosed in document D20A.

Enzyme containing microgranules with an average size between 25 and 350 microns were disclosed in document D4 where it was also stated in general terms that "Microgranules of a small particle size are most desirable, as they may be evenly distributed through feed and allow rapid release of enzymes" (paragraph bridging pages 7 and 8). Similarly, in document D21 it was stated that enzyme coated carrier particles with a grain size from 50 to 600 microns provided good mixing properties in food or feed (column 1, lines 13 to 20).

Regarding the argument that particles with a size of less than 100 microns tended to agglomerate, the board notes that this statement, taken from document D10, referred to the properties of carrier particles in a fluid bed granulator but not to the mixing properties of the final coated product. Moreover, even if it were true that carrier particles of less than 100 microns tended to agglomerate in the fluid bed granulator it would still be possible to obtain microgranules with an average size between 100 and 200 microns. (Note in this context that only about 11% of the microgranules of Example 5 of the patent in suit have a size of less than 90 microns.)

16. Based on the available prior art, the board is therefore convinced that there was no prejudice against the production of enzyme-coated granules with an average size between 20 to 200 microns, that there was a general interest in producing microgranules with an average size from e.g. 25 to 350 microns (cf. document D4), and that the procedure of document D20A could be easily adapted as needed. In the absence of any unexpected properties of the claimed microgranules, the board concludes that the selection of microgranules with an average size from 20 to 200 microns, which corresponds to the lower half of the size range held to be desirable in document D4, lacks an inventive step.

17. Therefore, the main request lacks an inventive step.

Admissibility of auxiliary requests I and II

18. Claim 1 of auxiliary request I is derived from claim 1 of auxiliary request III filed with the grounds of appeal. It contains additional amendments concerning the specification of the binder as hydrolysed starch, and a limitation of the average size from 20 to 400 microns to 20 to 200 microns.

Claim 1 of auxiliary request II is also derived from claim 1 of auxiliary request III filed with the grounds of appeal. The additional amendments concern the specification of the binder as hydrolysed starch and of the disintegrant as corn syrup solids, respectively, and a limitation of the average size from 20 to 400 microns to 20 to 200 microns.

19. With its statement of grounds of appeal, the appellant submitted auxiliary requests I to V and requested that it be allowed to file further requests "should it be needed" (cf. pages 11 and 12 of the statement of grounds).

20. The purpose of an oral hearing in appeal proceedings is to give the parties an opportunity to argue their case but not to give an appellant patentee the opportunity to repeatedly modify its requests until an acceptable set of claims is found (see among others T 47/03 of 27 September 2005; T 745/03 of 22 September 2005; T 221/06 of 24 July 2008 and R 11/08 of 6 April 2009; T 565/07 of 10 September 2009; T 1685/07 of 4 August 2010 and R 5/11 of 22 August 2011; T 1509/09 of 5 July 2012).

21. Claim 1 of both auxiliary requests contains specific combinations of features which in this form were never before presented in opposition or in appeal proceedings. Admitting the requests at this stage of the proceedings would therefore require the assessment of new issues and lead to procedural delays.

22. For this reason, the board, exercising its discretion under Article 13(1) RPBA, decided not to admit auxiliary requests I and II.

Request for finding of a substantial procedural violation

23. The opposition division had set a time limit of 15 March 2007 for the filing of further observations under the provisions of Rule 116 EPC. Document D20, an English translation of the abstract and claims 1 to 10 of Chinese Patent number CN 1051197, was filed on the last day of this time limit, i.e. two months before the oral proceedings were held. Document 20A, the English translation of the full Chinese document, was filed on 30 March 2007. Both opponents considered these documents highly relevant. With letter dated 11 May 2007, the patent proprietor (appellant) filed amended claim sets and requested that the oral proceedings be adjourned should the opposition division consider issuing a decision adverse to it on the basis of the newly filed evidence. Oral proceedings were held on 15 May 2007 and the opposition division decided to admit the documents into the proceedings but did not grant a request for postponement of the oral proceedings.

24. The appellant did not contest the relevance of documents D20 and D20A and their admission into the proceedings. The appellant however submitted that the opposition division committed a substantial procedural violation by not granting its request to adjourn the oral proceedings, and requested that the case be referred back to the opposition division "[u]nless the Board forms the view that the OD's finding of lack of inventive step over D20/D2OA should be overturned ...". In the auxiliary it requested that the board refer certain questions of law to the Enlarged Board of Appeal (cf. item IV above).

25. Regarding the review of first instance discretionary decisions, it is established jurisprudence of the boards of appeal that "If the way in which a department of first instance has exercised its discretion on a procedural matter is challenged in an appeal, it is not the function of a board of appeal to review all the facts and circumstances of the case as if it were in the place of the department of first instance, and to decide whether or not it would have exercised such discretion in the same way as the department of first instance. A board of appeal should only overrule the way in which a department of first instance has exercised its discretion if the board concludes it has done so according to the wrong principles, or without taking into account the right principles, or in an unreasonable way" (Case law of the Boards of Appeal, 6th edition, VII.E.6.6).

26. Document D20A was filed six weeks before oral proceedings were held but after the time limit set under Rule 116 EPC.

The abstract of document D20, which was filed in time, refers to the use of a granular enzyme preparation inter alia in fodder. Independent claims 1 and 7 of document D20 provide detailed technical information of the process and the apparatus, respectively, used for making the enzyme preparation. Dependent claim 2 discloses that regulation of the classification gas flow is used to control particle size, and dependent claims 5 and 6 specify the use of food grade binders and a food grade coating agent, respectively.

While the late filed document D20A provides a more extensive description of the method and apparatus used for preparing the microgranules, it does not provide technical information of more relevance to the present case than document D20.

The fact that document D20A was filed late is very much mitigated by the fact that document D20 contains virtually the same relevant information as document D20A, and the latter merely confirms the contents of document D20. Therefore, the Board takes the view that the opposition division, in admitting document D20A and in not granting the request for postponement of the oral proceedings, did not commit a substantial procedural violation but rather exercised its discretion correctly.

Consequently, the board sees no reason to remit the case back to the first instance.

Referral of a question of law to the Enlarged Board of Appeal

27. The appellant requested that certain questions of law be referred to the Enlarged Board of Appeal should the board not grant its request for remittal to the first instance (cf. paragraph XIV, above).

28. According to Article 112 EPC, questions of law shall be referred to the Enlarged Board of Appeal if the board of appeal considers that a decision is required in order to ensure uniform application of the law or if a point of law of fundamental importance arises.

29. The boards of appeal have consistently held that a discretionary decision of an opposition division should only be overruled if a board concludes that the opposition division exercised its discretion according to the wrong legal principles, or without taking into account the right principles, or in an unreasonable way (cf. point 25, above). Thus, there is no divergent application of the law in this respect.

Neither can the issue bee considered to be of fundamental or even general importance, as the opposition division took its decision based on the specifics of the case, i.e. the similar technical contents of documents D20 and D20A. As held above, the opposition division under such circumstances cannot be faulted for reaching the conclusion that the late filing of the complete document did not prejudice the patentee's possibility of properly defending itself during oral proceedings.

30. In view of the above, the board sees no reason to refer any questions of law to the Enlarged Board of Appeal.

31. Since there is no allowable request, the appeal has to be dismissed.